An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension

被引：0

作者：

Jongmin Kim

Yujung Kang

Yoko Kojima

Janet K Lighthouse

Xiaoyue Hu

Micheala A Aldred

Danielle L McLean

Hyekyung Park

Suzy A Comhair

Daniel M Greif

Serpil C Erzurum

Hyung J Chun

机构：

[1] Yale Cardiovascular Research Center,Department of Internal Medicine

[2] Section of Cardiovascular Medicine,Department of Pathobiology

[3] Yale University School of Medicine,undefined

[4] Genomic Medicine Institute,undefined

[5] The Lerner Institute,undefined

[6] The Cleveland Clinic Foundation,undefined

[7] The Lerner Institute,undefined

[8] The Cleveland Clinic Foundation,undefined

来源：

Nature Medicine | 2013年 / 19卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Vascular homeostasis in the lung is disturbed in pulmonary arterial hypertension. Jongmin Kim et al. delineate a new signaling axis controlling endothelial cell proliferation and cytokine production that is dysregulated in pulmonary endothelial cells from individuals with this disease. In this axis, the peptide apelin controls expression of the cytokine FGF2, a mitogen for endothelial and vascular smooth-muscle cells, through effects on two microRNAs. The authors also demonstrated the functional importance of these miRNAs in rat models of pulmonary hypertension.

引用

页码：74 / 82

页数：8

共 36 条

[1] An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension
Kim, Jongmin
Kang, Yujung
Kojima, Yoko
Lighthouse, Janet K.
Hu, Xiaoyue
Aldred, Micheala A.
McLean, Danielle L.
Park, Hyekyung
Comhair, Suzy A.
Greif, Daniel M.
Erzurum, Serpil C.
Chun, Hyung J.
NATURE MEDICINE, 2013, 19 (01) : 74 - 82
[2] Il-13 Accelerates The Proliferation Of Pulmonary Artery Endothelial Cells Via Down-Regulation Of Mir-424 And Mir-503
Takagi, K.
Matsuyama, T.
Mataki, H.
Kamikawaji, K.
Kumamoto, T.
Watanabe, M.
Mizuno, K.
Yamakuchi, M.
Inoue, H.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195
[3] Mir-424 and Mir-503 Regulates Cobll1 Expression during the CML Progression
Han, Seung Hun
Kim, Soo-Hyun
Hyoung-June, Kim
Yoonsung, Lee
Choi, Soo-Young
Gyeongsin, Park
Do-Hyun, Kim
Aram, Lee
Jongmin, Kim
Je-Min, Choi
Yonghwan, Kim
Kyungjae, Myung
Hongtae, Kim
Kim, Dong-Wook
BLOOD, 2017, 130
[4] IL-13 Enhances Mecenchymal Transition of Pulmonary Artery Endothelial Cells Through Down-Regulation of miR-424 and miR-503 In Vitro
Takagi, K.
Yamakuchi, M.
Matsuyama, T.
Misono, S.
Machida, K.
Hashiguchi, T.
Inoue, H.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
[5] Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation
Forrest, A. R. R.
Kanamori-Katayama, M.
Tomaru, Y.
Lassmann, T.
Ninomiya, N.
Takahashi, Y.
de Hoon, M. J. L.
Kubosaki, A.
Kaiho, A.
Suzuki, M.
Yasuda, J.
Kawai, J.
Hayashizaki, Y.
Hume, D. A.
Suzuki, H.
LEUKEMIA, 2010, 24 (02) : 460 - 466
[6] Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation
Forrest, A. R. R.
Kanamori-Katayama, M.
Tomaru, Y.
Lassmann, T.
Ninomiya, N.
Takahashi, Y.
de Hoon, M. J. L.
Kubosaki, A.
Kaiho, A.
Suzuki, M.
Yasuda, J.
Kawai, J.
Hayashizaki, Y.
Hume, D. A.
Suzuki, H.
DIFFERENTIATION, 2010, 80 : S31 - S31
[7] Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation
A R R Forrest
M Kanamori-Katayama
Y Tomaru
T Lassmann
N Ninomiya
Y Takahashi
M J L de Hoon
A Kubosaki
A Kaiho
M Suzuki
J Yasuda
J Kawai
Y Hayashizaki
D A Hume
H Suzuki
Leukemia, 2010, 24 : 460 - 466
[8] Loss of miR-424 and miR-503 promotes decidualization of human endometrial stromal cells by increasing SCARA5 expression
Yamaguchi, Tetsu
Takamura, Masashi
Tochigi, Hideno
Mizuno, Yumi
Mizuno, Yosuke
Sato, Tomomi
Tamaru, Shunsuke
Kusama, Kazuya
Tamura, Kazuhiro
Kamei, Yoshimasa
Kajihara, Takeshi
MEDICAL MOLECULAR MORPHOLOGY, 2025,
[9] MiR-424/503-Mediated Rictor Upregulation Promotes Tumor Progression
Oneyama, Chitose
Kito, Yoriko
Asai, Rei
Ikeda, Jun-ichiro
Yoshida, Takuya
Okuzaki, Daisuke
Kokuda, Rie
Kakumoto, Kyoko
Takayama, Ken-ichi
Inoue, Satoshi
Morii, Eiichi
Okada, Masato
PLOS ONE, 2013, 8 (11):
[10] Aberrant Endothelial FGF Signaling Due to Disruption of MicroRNAs 424/503 in Pulmonary Arterial Hypertension
Kim, Jongmin
Kojima, Yoko
Kang, Yujung
Aldred, Micheala
McLean, Danielle
Comhair, Suzy
Erzurum, Serpil
Chun, Hyung J.
CIRCULATION, 2011, 124 (21)

← 1 2 3 4 →