Synthesis of chiral linear and macrocyclic candidates: III. Synthesis and antimicrobial activity of linear tetrapeptide and macrocyclic pentapeptide Schiff bases

被引：0
|
作者：
Mohammed E. Azab
Abd El-Galil E. Amr
机构：
[1] Ain Shams University,Chemistry Department, Faculty of Science
[2] King Saud University,Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC)
[3] National Research Center,Applied Organic Chemistry Department
来源：
Russian Journal of General Chemistry | 2015年 / 85卷
关键词：
bicyclohexaazatetracarboxamides; macrocyclic pentapeptides; Schiff bases; antimicrobial activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of tetrapeptide Schiff bases and a macrocyclic pentapeptide were synthesized using Nα-dinicotinoyl-bis[L-leucyl-L-phenylalaninyl acid hydrazide] derivative and macrocyclic pentapeptide ester as starting materials and were screened for antimicrobial activity. Some of the newly synthesized compounds exhibited better antimicrobial effect compared to the reference controls. The structures of the newly synthesized compounds were confirmed by IR, NMR, and mass spectral data and elemental analyses.
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页码：1513 / 1521
页数：8
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