Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity

被引：0
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作者：
Melissa M Matthews
Justin M Thomas
Yuxuan Zheng
Kiet Tran
Kelly J Phelps
Anna I Scott
Jocelyn Havel
Andrew J Fisher
Peter A Beal
机构：
[1] University of California,Department of Chemistry
[2] Davis,Department of Molecular and Cellular Biology
[3] University of California,undefined
[4] Davis,undefined
来源：
Nature Structural & Molecular Biology | 2016年 / 23卷
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摘要：
Crystal structures of the human ADAR2 deaminase domain in complex with RNA duplexes reveal the mechanisms for ADAR2's action and explain its substrate preference. The work also provides a rationale to understand disease-related mutations.
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页码：426 / 433
页数：7
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