Circulating tumor cells in breast cancer: applications in personalized medicine

被引：0
|
作者：
Jin Sun Lee
Mark Jesus M. Magbanua
John W. Park
机构：
[1] University of California San Francisco,Division of Hematology/Oncology, Helen Diller Family Comprehensive Cancer Center
来源：
Breast Cancer Research and Treatment | 2016年 / 160卷
关键词：
Breast cancer; Circulating tumor cells (CTCs); Personalized medicine; HER2; Estrogen receptor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent technological advancements in rare cell analysis have facilitated the detection of circulating tumor cells (CTCs) in the blood of patients diagnosed with breast and other types of cancers. Numerous clinical studies involving the enumeration of CTCs in breast cancer patients have unequivocally demonstrated the prognostic value of these cells. Evidence from recent molecular studies indicates that CTCs may be potential surrogate markers for systemic disease. As such, real-time assessment of therapeutic biomarkers in breast CTCs, such as the estrogen receptor (ER) and the human epidermal growth factor receptor 2 (HER2), may have a tremendous impact in guiding-targeted cancer therapy. In this review, we discuss the clinical implications of CTC detection and its potential utility for personalized medicine in breast cancer.
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页码：411 / 424
页数：13
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