Thioredoxin-interacting protein regulates insulin transcription through microRNA-204

被引：0
|
作者：
Guanlan Xu
Junqin Chen
Gu Jing
Anath Shalev
机构：
[1] Comprehensive Diabetes Center,Department of Medicine, Division of Endocrinology
[2] Diabetes and Metabolism,undefined
[3] University of Alabama at Birmingham,undefined
来源：
Nature Medicine | 2013年 / 19卷
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学科分类号：
摘要：
Thioredoxin-interacting protein (TXNIP) regulates the redox potential of cells and has previously been found to be upregulated in diabetic states. In a new study, Anath Shalev and colleagues show that TXNIP upregulates the expression of miR-204, which in turn downregulates the expression of MAFA, a key transcription factor regulating insulin expression. These results could further explain the progression of diabetes.
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页码：1141 / 1146
页数：5
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