The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes

被引:0
|
作者
Min Lv
Yuanzhen Cai
Weikun Hou
Kan Peng
Ke Xu
Chao Lu
Wenxing Yu
Weisong Zhang
Lin Liu
机构
[1] Xi’an JiaoTong University,Osteonecrosis and Joint Reconstruction Ward, Honghui Hospital
来源
Inflammation Research | 2022年 / 71卷
关键词
Osteoarthritis; SND1; GPX4; HSPA5; Chondrocyte; Ferroptosis;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:461 / 472
页数:11
相关论文
共 6 条
  • [1] The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes
    Lv, Min
    Cai, Yuanzhen
    Hou, Weikun
    Peng, Kan
    Xu, Ke
    Lu, Chao
    Yu, Wenxing
    Zhang, Weisong
    Liu, Lin
    INFLAMMATION RESEARCH, 2022, 71 (04) : 461 - 472
  • [2] HSPA5 repressed ferroptosis to promote colorectal cancer development by maintaining GPX4 stability
    Wang, Ronglin
    Hua, Lei
    Ma, Peixiang
    Song, Yang
    Min, Jie
    Guo, Yongdong
    Yang, Cheng
    Li, Junqiang
    Su, Haichuan
    NEOPLASMA, 2022, 69 (05) : 1054 - 1069
  • [3] Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways
    Tuncer, Cengiz
    Hacioglu, Ceyhan
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2024, 28 (07)
  • [4] IL-1(3-induced mesenchymal stem cell-derived exosomes inhibit neuronal ferroptosis in intracerebral hemorrhage through the HSPA5/GPX4 axis
    Li, Jiameng
    Lin, Long
    Yu, Zhengtao
    He, Jun
    Li, You
    Jiang, Junwen
    Xia, Ying
    BRAIN RESEARCH, 2024, 1845
  • [5] 4-tert-butylphenol triggers common carp hepatocytes ferroptosis via oxidative stress, iron overload, SLC7A11/GSH/GPX4 axis, and ATF4/ HSPA5/GPX4 axis
    Cui, Jiawen
    Zhou, Qin
    Yu, Meijin
    Liu, Yuhao
    Teng, Xiaohua
    Gu, Xianhong
    ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2022, 242
  • [6] STUB1-mediated ubiquitination and degradation of NSUN2 promotes hepatocyte ferroptosis by decreasing m5C methylation of Gpx4 mRNA
    Zhang, Xiaotian
    Zhang, Yihua
    Li, Rongrong
    Li, Yibo
    Wang, Qi
    Wang, Ying
    Chen, Xinying
    Wang, Weihua
    Pang, Erli
    Li, Yanyan
    Wang, Jia
    Zheng, Jinping
    Zhang, Junjie
    CELL REPORTS, 2024, 43 (11):