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DNA methylation in peripheral tissues and left-handedness
被引:0
|作者:
Veronika V. Odintsova
Matthew Suderman
Fiona A. Hagenbeek
Doretta Caramaschi
Jouke-Jan Hottenga
René Pool
Conor V. Dolan
Lannie Ligthart
Catharina E. M. van Beijsterveldt
Gonneke Willemsen
Eco J. C. de Geus
Jeffrey J. Beck
Erik A. Ehli
Gabriel Cuellar-Partida
David M. Evans
Sarah E. Medland
Caroline L. Relton
Dorret I. Boomsma
Jenny van Dongen
机构:
[1] Vrije Universiteit Amsterdam,Department of Biological Psychology
[2] AR&D Research Institute,Amsterdam Reproduction and Development
[3] Amsterdam Public Health Research Institute,MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School
[4] University of Bristol,The University of Queensland Diamantina Institute
[5] Avera Institute for Human Genetics,Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics
[6] The University of Queensland,Department of Human Genetics
[7] QIMR Berghofer Medical Research Institute,Department of Internal Medicine
[8] Leiden University Medical Center,Department of Genetic Epidemiology
[9] Leiden University Medical Center,Department of Psychiatry, VU University Medical Center
[10] ErasmusMC,Department of Genetics, University Medical Centre Groningen
[11] ErasmusMC,Department of Internal Medicine and School for Cardiovascular Diseases (CARIM)
[12] Neuroscience Campus Amsterdam,Department of Gerontology and Geriatrics
[13] University of Groningen,Department of Neurology, Brain Center Rudolf Magnus
[14] Maastricht University Medical Center,Department of Epidemiology
[15] Leiden University Medical Center,Sequence Analysis Support Core
[16] University Medical Center Utrecht,Genomics Coordination Center, University Medical Center Groningen
[17] ErasmusMC,Medical Statistics Section, Department of Medical Statistics and Bioinformatics
[18] Leiden University Medical Center,undefined
[19] SURFsara,undefined
[20] University of Groningen,undefined
[21] Leiden University Medical Center,undefined
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摘要:
Handedness has low heritability and epigenetic mechanisms have been proposed as an etiological mechanism. To examine this hypothesis, we performed an epigenome-wide association study of left-handedness. In a meta-analysis of 3914 adults of whole-blood DNA methylation, we observed that CpG sites located in proximity of handedness-associated genetic variants were more strongly associated with left-handedness than other CpG sites (P = 0.04), but did not identify any differentially methylated positions. In longitudinal analyses of DNA methylation in peripheral blood and buccal cells from children (N = 1737), we observed moderately stable associations across age (correlation range [0.355–0.578]), but inconsistent across tissues (correlation range [− 0.384 to 0.318]). We conclude that DNA methylation in peripheral tissues captures little of the variance in handedness. Future investigations should consider other more targeted sources of tissue, such as the brain.
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