If phosphatases go up, memory goes down

被引：0
|
作者：
G. Riedel
机构：
[1] University of Aberdeen,
[2] Department of Biomedical Sciences,undefined
[3] Institute of Medical Sciences,undefined
[4] Foresterhill,undefined
[5] Aberdeen AB25 2ZD (UK),undefined
[6] Fax +44 1224 273019,undefined
[7] e-mail: g.riedel@abdn.ac.uk,undefined
来源：
Cellular and Molecular Life Sciences CMLS | 1999年 / 55卷
关键词：
Key words. Hippocampus; synaptic plasticity; memory formation; protein kinase A; protein phosphatase 1 and 2A; calcineurin.;
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摘要：
Previous work has provided conclusive support for a role of various protein kinases in processes underlying learning and memory formation. While these processes are not yet established in full detail, it is interesting to entertain the idea of protein phosphatases being involved in such mechanisms as well. Recent advances in this respect have provided preliminary support of this view. From the pharmacological as well as the transgenic analysis, it appears that especially the calcineurin/inhibitor-1 cascade plays an important role in the transition of intermediate-term into long-term memory formation.
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页码：549 / 553
页数：4
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