Brn-3a neuronal transcription factor functional expression in human prostate cancer

被引：0

作者：

J K J Diss

D J Faulkes

M M Walker

A Patel

C S Foster

V Budhram-Mahadeo

M B A Djamgoz

D S Latchman

机构：

[1] Medical Molecular Biology Unit,Department of Histopathology

[2] Institute of Child Health,Department of Urology

[3] University College London,Department of Cellular and Molecular Pathology

[4] Imperial College School of Medicine,Department of Biological Sciences

[5] St Mary's Hospital,undefined

[6] Imperial College School of Medicine,undefined

[7] St Mary's Hospital,undefined

[8] University of Liverpool,undefined

[9] Neuroscience Solutions to Cancer Research Group,undefined

[10] Imperial College London,undefined

[11] Birkbeck College,undefined

[12] University of London,undefined

来源：

Prostate Cancer and Prostatic Diseases | 2006年 / 9卷

关键词：

Brn-3; real-time PCR; immunohistochemistry; growth; Nav1.7;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Neuroendocrine differentiation has been associated with prostate cancer (CaP). Brn-3a (short isoform) and Brn-3c, transcriptional controllers of neuronal differentiation, were readily detectable in human CaP both in vitro and in vivo. Brn-3a expression, but not Brn-3c, was significantly upregulated in >50% of tumours. Furthermore, overexpression of this transcription factor in vitro (i) potentiated CaP cell growth and (ii) regulated the expression of a neuronal gene, the Nav1.7 sodium channel, concomitantly upregulated in human CaP, in an isoform-specific manner. It is concluded that targeting Brn-3a could be a useful strategy for controlling the expression of multiple genes that promote CaP.

引用

页码：83 / 91

页数：8

共 50 条

[1] Brn-3a neuronal transcription factor functional expression in human prostate cancer
Diss, JKJ
Faulkes, DJ
Walker, MM
Patel, A
Foster, CS
Budhram-Mahadeo, V
Djamgoz, MBA
Latchman, DS
PROSTATE CANCER AND PROSTATIC DISEASES, 2006, 9 (01) : 83 - 91
[2] The Brn-3a transcription factor
Latchman, DS
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1998, 30 (11): : 1153 - 1157
[3] Alternative splicing of the Brn-3a and Brn-3b transcription factor RNAs is regulated in neuronal cells
Liu, YZ
Dawson, SJ
Latchman, DS
JOURNAL OF MOLECULAR NEUROSCIENCE, 1996, 7 (01) : 77 - 85
[4] Brn-3a, a neuronal transcription factor of the POU gene family: Indications for its involvement in cancer and angiogenesis
Vincenzo Chiarugi
Mario Del Rosso
Lucia Magnelli
Molecular Biotechnology, 2002, 22 : 123 - 127
[5] Brn-3a, a neuronal transcription factor of the POU gene family: Indications for its involvement in cancer and angiogenesis
Chiarugi, V
Del Rosso, M
Magnelli, L
MOLECULAR BIOTECHNOLOGY, 2002, 22 (02) : 123 - 127
[6] The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins
Smith, MD
Dawson, SJ
Latchman, DS
MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (01) : 345 - 354
[7] Doppel expression is regulated by the Brn-3a and Brn-3b transcription factors
Calissano, M
Ensor, E
Brown, DR
Latchman, DS
NEUROREPORT, 2004, 15 (03) : 483 - 486
[8] The two activation domains of the Brn-3a transcription factor have distinct functional properties
Begbie, JL
Latchman, DS
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1997, 29 (12): : 1493 - 1500
[9] Phosphorylation of the Brn-3a transcription factor is modulated during differentiation and regulates its functional activity
Calissano, M
Faulkes, D
Latchman, DS
MOLECULAR BRAIN RESEARCH, 2005, 141 (01): : 10 - 18
[10] Coordinate induction of the three neurofilament genes by the Brn-3a transcription factor
Smith, MD
Morris, PJ
Dawson, SJ
Schwartz, ML
Schlaepfer, WW
Latchman, DS
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (34) : 21325 - 21333

← 1 2 3 4 5 →