p53 status determines the role of autophagy in pancreatic tumour development

被引：0

作者：

Mathias T. Rosenfeldt

Jim O’Prey

Jennifer P. Morton

Colin Nixon

Gillian MacKay

Agata Mrowinska

Amy Au

Taranjit Singh Rai

Liang Zheng

Rachel Ridgway

Peter D. Adams

Kurt I. Anderson

Eyal Gottlieb

Owen J. Sansom

Kevin M. Ryan

机构：

[1] Cancer Research UK Beatson Institute,

[2] Garscube Estate,undefined

[3] Switchback Road,undefined

[4] Glasgow G61 1BD,undefined

[5] UK,undefined

[6] Institute of Cancer Studies,undefined

[7] University of Glasgow,undefined

[8] Garscube Estate,undefined

[9] Switchback Road,undefined

[10] Glasgow G611BD,undefined

[11] UK,undefined

来源：

Nature | 2013年 / 504卷

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暂无

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学科分类号：

摘要：

In a mouse model of pancreatic tumours driven by Kras mutations, the outcome of suppressing autophagy is shown to depend on the status of p53: if p53 is intact, deletion of key autophagy genes blocks the progression of pre-cancerous lesions to aggressive carcinomas; however, in the absence of p53, loss of autophagy accelerates tumorigenesis, accompanied by deregulation of cancer cell metabolism.

引用

页码：296 / 300

页数：4

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