Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy

被引：0
|
作者：
Andrea Katharina Lindner
Felizian Lackner
Piotr Tymoszuk
Dominik Andreas Barth
Andreas Seeber
Florian Kocher
Bettina Toth
Margarethe Hochleitner
Martin Pichler
Renate Pichler
机构：
[1] Medical University of Innsbruck,Department of Urology, Comprehensive Cancer Center Innsbruck
[2] Data Analytics As a Service Tirol,Division of Oncology, Department of Internal Medicine
[3] Medical University of Graz,Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck
[4] Medical University of Innsbruck,Department of Gynecological Endocrinology and Reproductive Medicine
[5] Medical University Innsbruck,Department of Internal Medicine, Gender Medicine Unit
[6] Medical University of Innsbruck,Translational Oncology
[7] University Hospital of Augsburg,undefined
来源：
Biology of Sex Differences | / 14卷
关键词：
Metastatic urothelial carcinoma; Immunotherapy; Overall survival; Sex hormones; Gonadotropins; Prognostic; Biomarkers;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Urothelial carcinoma (UC) presents as aggressive disease with a greater incidence in men, yet a more aggressive course of disease in women. Patients with metastatic UC receive a chemotherapy regimen as the gold standard, based on an included platin substance. In the case of having contraindications to chemotherapy, checkpoint immunotherapy, priming the immune system to the tumor, is the treatment of choice. Furthermore, immunotherapy is used as second line therapy in progressive disease after chemotherapy and as maintenance therapy in stable tumor conditions after completing the chemotherapy regimen.
引用
收藏
相关论文
共 50 条
  • [1] Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy
    Lindner, Andrea Katharina
    Lackner, Felizian
    Tymoszuk, Piotr
    Barth, Dominik Andreas
    Seeber, Andreas
    Kocher, Florian
    Toth, Bettina
    Hochleitner, Margarethe
    Pichler, Martin
    Pichler, Renate
    BIOLOGY OF SEX DIFFERENCES, 2023, 14 (01)
  • [2] The prognostic significance of histologic variant on survival outcomes in patients with metastatic urothelial carcinoma receiving immune checkpoint inhibitor therapy
    Tsung-Han Tsai
    Po-Jung Su
    Shih-Yu Huang
    Ming-Chun Kuo
    Chang-Ting Lin
    Chia-Che Wu
    Hao-Lun Luo
    Chien-Hsu Chen
    Chih-Chi Chou
    Ting-Ting Liu
    Chun-Chieh Huang
    Kai-Lung Tsai
    Yu-Li Su
    BMC Cancer, 23 (1)
  • [3] The prognostic significance of histologic variant on survival outcomes in patients with metastatic urothelial carcinoma receiving immune checkpoint inhibitor therapy
    Tsai, Tsung-Han
    Su, Po-Jung
    Huang, Shih-Yu
    Kuo, Ming-Chun
    Lin, Chang-Ting
    Wu, Chia-Che
    Luo, Hao-Lun
    Chen, Chien-Hsu
    Chou, Chih-Chi
    Liu, Ting-Ting
    Huang, Chun-Chieh
    Tsai, Kai-Lung
    Su, Yu-Li
    BMC CANCER, 2023, 23 (01)
  • [4] Immune checkpoint inhibition in metastatic urothelial carcinoma
    Bedke, Jens
    Todenhoefer, Tilman
    Stenzl, Arnulf
    AKTUELLE UROLOGIE, 2018, 49 (02) : 178 - 186
  • [5] Subsequent Systemic Therapy following Platinum and Immune Checkpoint Inhibitors in Metastatic Urothelial Carcinoma
    Hong, Joohyun
    Sung, Hyun Hwan
    Jeong, Byong Chang
    Park, Se Hoon
    BIOMEDICINES, 2022, 10 (08)
  • [6] Immunotherapy in metastatic urothelial carcinoma: focus on immune checkpoint inhibition
    Siefker-Radtke, Arlene
    Curti, Brendan
    NATURE REVIEWS UROLOGY, 2018, 15 (02) : 112 - 124
  • [7] Immunotherapy in metastatic urothelial carcinoma: focus on immune checkpoint inhibition
    Arlene Siefker-Radtke
    Brendan Curti
    Nature Reviews Urology, 2018, 15 : 112 - 124
  • [8] Biomarkers of the Response to Immune Checkpoint Inhibitors in Metastatic Urothelial Carcinoma
    Chen, Siteng
    Zhang, Ning
    Wang, Tao
    Zhang, Encheng
    Wang, Xiang
    Zheng, Junhua
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [9] Immune Checkpoint Inhibitors and Long-term Survival of Patients With Metastatic Urothelial Cancer
    Zhu, Alec
    Garcia, Jorge Alberto
    Faltas, Bishoy
    Grivas, Petros
    Barata, Pedro
    Shoag, Jonathan E.
    JAMA NETWORK OPEN, 2023, 6 (04)
  • [10] Chemotherapy following immune checkpoint inhibitors in patients with locally advanced or metastatic urothelial carcinoma
    Meynard, Lucie
    Dinart, Derek
    Delaunay, Blandine
    Flechon, Aude
    Saldana, Carolina
    Lefort, Felix
    Gravis, Gwenaelle
    Thiery-Vuillemin, Antoine
    Cancel, Mathilde
    Coquan, Elodie
    Ladoire, Sylvain
    Maillet, Denis
    Rolland, Frederic
    Boughalem, Elouen
    Martin, Sophie
    Laramas, Mathieu
    Crouzet, Laurence
    Abbar, Baptiste
    Falkowski, Sabrina
    Pouessel, Damien
    Roubaud, Guilhem
    EUROPEAN JOURNAL OF CANCER, 2022, 175 : 43 - 53
12345