Identification and analytical properties of acetyl fentanyl metabolites

被引：0
|
作者：
A. B. Melent’ev
S. S. Kataev
O. N. Dvorskaya
机构：
[1] Chelyabinsk Regional Bureau of Forensic Medical Examination,Chair of Toxicological Chemistry, Perm State Pharmaceutical Academy
[2] Perm Regional Bureau of Forensic Medical Examination,undefined
[3] Ministry for Healthcre of the Russian Federation,undefined
来源：
Journal of Analytical Chemistry | 2015年 / 70卷
关键词：
designer drugs; acetyl fentanyl; metabolism; gas chromatography; HPLC; mass spectrometry detection;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Acetyl fentanyl is a novel designer drug substance, a derivative of fentanyl. Its major metabolites were identified in samples of urine from consumers of acetyl fentanyl using gas chromatography and high-performance liquid chromatography with mass spectrometry detection. Structures of metabolites were proposed and confirmed by their fragmentation on electron impact and atmospheric pressure chemical ionization. The mass spectral and chromatographic properties of some derivatives of acetyl fentanyl metabolites were determined. The main path of the biotransformation of acetyl fentanyl is the hydroxylation of the phenylethyl moiety in the molecule.
引用
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页码：240 / 248
页数：8
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