PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1

被引：0

作者：

Gang Chen

Yong Ho Kim

Hui Li

Hao Luo

Da-Lu Liu

Zhi-Jun Zhang

Mark Lay

Wonseok Chang

Yu-Qiu Zhang

Ru-Rong Ji

机构：

[1] Duke University Medical Center,Department of Anesthesiology

[2] Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education,Department of Physiology

[3] Co-Innovation Center of Neuroregeneration,Department of Neurobiology

[4] Nantong University,undefined

[5] College of Medicine,undefined

[6] Gachon University,undefined

[7] Institute of Neurobiology,undefined

[8] Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,undefined

[9] Collaborative Innovation Center for Brain Science,undefined

[10] Fudan University,undefined

[11] Duke University Medical Center,undefined

来源：

Nature Neuroscience | 2017年 / 20卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The authors identify programmed cell death ligand-1 (PD-L1), an immunity suppressor produced by cancer cells, as a new pain inhibitor and a neuromodulator. They report that PD-L1 is produced by melanoma and normal neural tissues and that it inhibits acute and chronic pain. Via activation of PD-1, its receptor, PD-L1 decreases the excitability of nociceptive neurons in mouse and human dorsal root ganglia.

引用

页码：917 / 926

页数：9

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[1] PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1
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[2] Author Correction: PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1
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[3] PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1 (vol 20, pg 917, 2017)
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