A novel natural mutation in HC-Pro responsible for mild symptomatology of Zucchini yellow mosaic virus (ZYMV, Potyvirus) in cucurbits

被引：0
|
作者：
Cecile Desbiez
M. Girard
H. Lecoq
机构：
[1] INRA,
[2] Unité de Pathologie Végétale UR407,undefined
来源：
Archives of Virology | 2010年 / 155卷
关键词：
Melon; Zucchini Yellow Mosaic Virus; Mild Strain; Silence Inhibition; Helper Component;
D O I：
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中图分类号：
学科分类号：
摘要：
A natural mild isolate of Zucchini yellow mosaic virus was found to contain a mutation in the helper component (HC-Pro) within a conserved motif, “CDNQLD”, located 12 residues downstream from the “FRNK” motif involved in symptom severity. Introducing the mutation in an infectious cDNA clone of ZYMV resulted in an almost complete absence of symptoms, although viral accumulation was only partially reduced. The FRNK(X)12CDNQLD sequence might be part of a larger motif that is conserved in potyviruses and plays a role in symptomatology and/or silencing inhibition.
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页码：397 / 401
页数：4
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