Region-specific growth restriction of brain following preterm birth

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作者
Sachiko Iwata
Reiji Katayama
Masahiro Kinoshita
Mamoru Saikusa
Yuko Araki
Sachio Takashima
Toshi Abe
Osuke Iwata
机构
[1] Kurume University School of Medicine,Department of Paediatrics and Child Health
[2] Centre for Developmental and Cognitive Neuroscience,Department of Radiology
[3] Kurume University School of Medicine,undefined
[4] Diagnostic Imaging Centre,undefined
[5] Kurume University Hospital,undefined
[6] Faculty of Informatics,undefined
[7] Shizuoka University,undefined
[8] Yanagawa Institute for Developmental Disabilities,undefined
[9] International University of Health and Welfare,undefined
[10] Kurume University School of Medicine,undefined
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摘要
Regional brain sizes of very-preterm infants at term-equivalent age differ from those of term-born peers, which have been linked with later cognitive impairments. However, dependence of regional brain volume loss on gestational age has not been studied in detail. To investigate the spatial pattern of brain growth in neonates without destructive brain lesions, head MRI of 189 neonates with a wide range of gestational age (24–42 weeks gestation) was assessed using simple metrics measurements. Dependence of MRI findings on gestational age at birth (Agebirth) and the corrected age at MRI scan (AgeMRI) were assessed. The head circumference was positively correlated with AgeMRI, but not Agebirth. The bi-parietal width, deep grey matter area and the trans-cerebellar diameter were positively correlated with both Agebirth and AgeMRI. The callosal thickness (positive), atrial width of lateral ventricle (negative) and the inter-hemispheric distance (negative) were exclusively correlated with Agebirth. The callosal thickness and cerebral/cerebellar transverse diameters showed predominant dependence on Agebirth over AgeMRI, suggesting that brain growth after preterm-birth was considerably restricted or even became negligible compared with that in utero. Such growth restriction after preterm birth may extensively affect relatively more matured infants, considering the linear relationships observed between brain sizes and Agebirth.
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