Association of dopamine receptor D5 gene polymorphism with peculiarities of voluntary attention in schizophrenic patients and their relatives

被引：0
|
作者：
V. E. Golimbet
M. V. Alfimova
I. K. Gritsenko
T. V. Lezheiko
R. Ebstein
机构：
[1] Russian Academy of Medical Sciences,Research Center of Mental Health
[2] Hebrew University,Department of Psychology, Scheinfeld Center on Human Genetics
来源：
Bulletin of Experimental Biology and Medicine | 2008年 / 145卷
关键词：
schizophrenia; dopamine D5 receptor gene; attention;
D O I：
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学科分类号：
摘要：
We studied the relationship between DRD5 gene polymorphism presented by microsatellites with cognitive signs in 152 schizophrenic patients, 81 mentally healthy relatives, and 125 mentally healthy control individuals. An association was found between DRD5 polymorphism with efficiency of visual voluntary attention in patients (p=0.02) and their relatives (p=0.006). Carriers of two copies of the 148-b.p. allele were characterized by low efficiency of attention.
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