Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

被引：0
|
作者：
Scott A Yuzwa
Xiaoyang Shan
Matthew S Macauley
Thomas Clark
Yuliya Skorobogatko
Keith Vosseller
David J Vocadlo
机构：
[1] Simon Fraser University,Department of Molecular Biology and Biochemistry
[2] Simon Fraser University,Department of Chemistry
[3] Drexel University College of Medicine,Department of Biochemistry and Molecular Biology
[4] Current address: Department of Chemical Physiology,undefined
[5] The Scripps Research Institute,undefined
[6] La Jolla,undefined
[7] California,undefined
[8] USA.,undefined
来源：
Nature Chemical Biology | 2012年 / 8卷 / 4期
关键词：
D O I：
10.1038/nchembio.797
中图分类号：
学科分类号：
摘要：
A compound that inhibits hydrolysis of O-GlcNAc groups decreases the neurodegenerative capacity of tau, a protein that forms neurofibrillary tangles in Alzheimer's disease.[graphic not available: see fulltext]
引用
收藏
页码：393 / 399
页数：6
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