Biocompatibility testing of novel multifunctional polymeric biomaterials for tissue engineering applications in head and neck surgery: an overview
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作者:
Dorothee Rickert
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机构:University of Ulm,Department of Otolaryngology and Head and Neck Surgery
Dorothee Rickert
Andreas Lendlein
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机构:University of Ulm,Department of Otolaryngology and Head and Neck Surgery
Andreas Lendlein
Ilka Peters
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机构:University of Ulm,Department of Otolaryngology and Head and Neck Surgery
Ilka Peters
Marsha A. Moses
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机构:University of Ulm,Department of Otolaryngology and Head and Neck Surgery
Marsha A. Moses
Ralf-Peter Franke
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机构:University of Ulm,Department of Otolaryngology and Head and Neck Surgery
Ralf-Peter Franke
机构:
[1] University of Ulm,Department of Otolaryngology and Head and Neck Surgery
[2] University of Ulm,Central Institute for Biomedical Engineering, Department for Biomaterials
[3] Institute of Biological Interface,Forschungszentrum Karlsruhe
[4] Institute of Chemistry,GKSS Forschungszentrum Geestacht GmbH
[5] Harvard Medical School Children’s Hospital,Department of Surgery and The Vascular Biology Program
来源:
European Archives of Oto-Rhino-Laryngology and Head & Neck
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2006年
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263卷
关键词:
Polymeric biodegradable materials;
Biocompatibility testing;
Tissue engineering;
Head and neck surgery;
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摘要:
Biomaterial research and tissue engineering are rapidly growing scientific fields that need an interdisciplinary approach where clinicians should be included from the onset. Biocompatibility testing in vitro and in vivo comprise the agarose-overlay test, the MTT test, direct cell seeding tests and the chorioallantoic membrane test for angiogenic effects, among others. Molecular biology techniques such as real-time polymerase chain reaction and microarray technology facilitate the investigation of tissue integration into biomaterials on a cellular and molecular level. The physicochemical characterization of biomaterials is conducted using such methods as X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). Excellent biocompatibility and biofunctionality were demonstrated for a series of recently developed multifunctional biodegradable, polymeric biomaterials both in vitro and in vivo. Novel, multifunctional polymeric biomaterials offer a highly specific adjustment to the physiological, anatomical and surgical requirements and can thereby facilitate new therapeutic options in head and neck surgery.
机构:
Univ Otago, Dept Food Sci, Ctr Bioengn & Nanomed, Bioengn Res Team, POB 56, Dunedin 9054, New ZealandUniv Otago, Dept Food Sci, Ctr Bioengn & Nanomed, Bioengn Res Team, POB 56, Dunedin 9054, New Zealand
Boni, Rossana
Ali, Azam
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机构:
Univ Otago, Dept Food Sci, Ctr Bioengn & Nanomed, Bioengn Res Team, POB 56, Dunedin 9054, New ZealandUniv Otago, Dept Food Sci, Ctr Bioengn & Nanomed, Bioengn Res Team, POB 56, Dunedin 9054, New Zealand
Ali, Azam
Shavandi, Amin
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机构:
Univ Otago, Dept Food Sci, Ctr Bioengn & Nanomed, Bioengn Res Team, POB 56, Dunedin 9054, New Zealand
Univ Libre Bruxelles, BioMatter Biomass Transformat Lab BTL, Ecole Polytech Bruxelles, EIB, Ave FD Roosevelt 50,CP 165-61, B-1050 Brussels, BelgiumUniv Otago, Dept Food Sci, Ctr Bioengn & Nanomed, Bioengn Res Team, POB 56, Dunedin 9054, New Zealand
Shavandi, Amin
Clarkson, Andrew N.
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机构:
Univ Otago, Brain Hlth Res Ctr, Dept Anat, POB 56, Dunedin 9054, New Zealand
Univ Otago, Brain Res New Zealand, POB 56, Dunedin 9054, New ZealandUniv Otago, Dept Food Sci, Ctr Bioengn & Nanomed, Bioengn Res Team, POB 56, Dunedin 9054, New Zealand