Gene expression profile changes in Eisenia fetida chronically exposed to PFOA

被引：0

作者：

Srinithi Mayilswami

Kannan Krishnan

Mallavarapu Megharaj

Ravi Naidu

机构：

[1] University of South Australia,Centre for Environmental Risk Assessment and Remediation

[2] Cooperative Research Centre for Contamination Assessment and Remediation of the Environment (CRC-CARE),Global Centre for Environmental Remediation, Faculty of Science and Information Technology

[3] The University of Newcastle,undefined

来源：

Ecotoxicology | 2016年 / 25卷

关键词：

Perfluorooctanoic acid (PFOA); Transcriptome assembly; Differential gene expression; Toxicogenomics;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Eisenia fetida is a terrestrial organism, which can be used to diagnose sub-lethal concentrations of PFOA by using molecular biomarkers. In order to identify potential molecular biomarkers, we have exposed E. fetida to 10 mg/kg of PFOA in soil for 8 months. The mRNA isolation, sequencing, transcriptome assembly followed by differential gene expression studies have revealed that genes that are involved in apoptotic process, reproduction, calcium signalling, neuronal development and lipid metabolism are predominantly affected. Highly specific genes that are altered by PFOA can be further validated and used as biomarker to detect sub-lethal concentrations of PFOA in the soil.

引用

页码：759 / 769

页数：10

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