Apical uptake of organic cations by human intestinal Caco-2 cells: putative involvement of ASF transporters

被引：0
|
作者：
F. Martel
D. Gründemann
C. Calhau
E. Schömig
机构：
[1] Department of Biochemistry,
[2] Faculty of Medicine,undefined
[3] 4200 Porto,undefined
[4] Portugal,undefined
[5] Institute of Pharmacology and Therapeutics,undefined
[6] Faculty of Medicine,undefined
[7] 4200 Porto,undefined
[8] Portugal,undefined
[9] Department of Pharmacology,undefined
[10] University of Heidelberg,undefined
[11] Im Neuenheimer Feld 366,undefined
[12] 69120 Heidelberg,undefined
[13] Germany,undefined
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 2001年 / 363卷
关键词：
Caco-2 cells MPP+ Brush-border membrane Extraneuronal monoamine transporter Organic cation transporter 1 Amphiphilic solute facilitator family;
D O I：
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中图分类号：
学科分类号：
摘要：
The aim of this work was to characterise the intestinal absorption of organic cations, by testing the possibility of involvement of known members of the amphiphilic solute facilitator (ASF) family in this process. For that purpose, the characteristics of the uptake of 1-methyl-4-phenylpyridinium, a model organic cation, at the brush-border membrane of Caco-2 cells were compared with those of the extraneuronal monoamine transporter (EMT)-mediated transport.
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页码：40 / 49
页数：9
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