Molecular Characterization of Virulent Newcastle Disease Virus Isolates from Chickens during the 1998 NDV Outbreak in Kazakhstan

被引:0
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作者
Andrey Bogoyavlenskiy
Vladimir Berezin
Alexey Prilipov
Eugeniy Usachev
Olga Lyapina
Svetlana Levandovskaya
Ilya Korotetskiy
Valentina Tolmacheva
Nailya Makhmudova
Svetlana Khudyakova
Gulnur Tustikbaeva
Irina Zaitseva
Elmira Omirtaeva
Olga Ermakova
Klara Daulbaeva
Saule Asanova
Aydyn Kydyrmanov
Marat Sayatov
Daniel King
机构
[1] Institute of Microbiology & Virology,U.S. Department of Agriculture, Agricultural Research Service
[2] D.I. Ivanovsky Institute of Virology,undefined
[3] Southeast Poultry Research Laboratory,undefined
来源
Virus Genes | 2005年 / 31卷
关键词
chicken; fusion gene; Newcastle disease virus; phylogenetic characterization; virulent;
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中图分类号
学科分类号
摘要
Newcastle disease virus (NDV) infects domesticated and wild birds throughout the world and has the possibility to cause outbreaks in chicken flocks in future. To assess the evolutionary characteristics of 10 NDV strains isolated from chickens in Kazakhstan during 1998 we investigated the phylogenetic relationships among these viruses and viruses described previously. For genotyping, fusion (F) gene phylogenetic analysis (nucleotide number 47-421) was performed using sequences of Kazakhstanian isolates as compared to sequences of selected NDV strains from GenBank. Phylogenetic analysis showed that all newly characterized strains belonged to the genetic group designated as VIIb. All strains possessed a virulent fusion cleavage site (RRQRR/F) belonging to velogenic or mesogenic pathotypes with intracerebral pathogenicity indexes (ICPI) varying from 1.05 to 1.87.
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页码:13 / 20
页数:7
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