Haploinsufficiency of NR3C1 drives glucocorticoid resistance in adult acute lymphoblastic leukemia cells by down-regulating the mitochondrial apoptosis axis, and is sensitive to Bcl-2 blockage

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作者
Haowen Xiao
Yingying Ding
Yang Gao
Li-Mengmeng Wang
Huafang Wang
Lijuan Ding
Xiaoqing Li
Xiaohong Yu
He Huang
机构
[1] Zhejiang University School of Medicine,Department of Hematology, Sir Run Run Shaw Hospital
[2] Zhejiang University,Institute of Hematology
[3] The People’s Hospital of Zhongshan City,Department of Hematology
[4] The First Affiliated Hospital,Bone Marrow Transplantation Center
[5] Zhejiang University School of Medicine,undefined
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Haploinsufficiency; NR3C1; Glucocorticoid resistance; Acute lymphoblastic leukemia; Mitochondrial apoptosis axis; Bcl-2 blockage;
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