Is there a role for Notch signalling in human breast cancer?

被引：0
|
作者：
Keith Brennan
Anthony MC Brown
机构：
[1] University of Manchester,School of Biological Sciences
[2] Strang Cancer Research Laboratory at The Rockefeller University,Department of Cell and Developmental Biology
[3] Weill Medical College of Cornell University,undefined
来源：
Breast Cancer Research | / 5卷
关键词：
breast cancer; Notch signalling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Aberrant Notch signalling has been observed in several human cancers, including acute T-cell lymphoblastic leukaemia and cervical cancer, and is strongly implicated in tumourigenesis. Unregulated Notch signalling in the mouse mammary gland leads to tumour formation. These results raise the possibility that Notch signalling might play a role in human breast cancer. There are currently few reports that address this question directly and this appears to be an area worthy of further investigation.
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