Molecular ablation of ventricular tachycardia after myocardial infarction

被引：0
|
作者：
Tetsuo Sasano
Amy D McDonald
Kan Kikuchi
J Kevin Donahue
机构：
[1] Heart and Vascular Research Center,Division of Cardiology
[2] MetroHealth Hospital,Division of Cardiology
[3] Case Western Reserve University School of Medicine,undefined
[4] Johns Hopkins University School of Medicine,undefined
[5] Kyushu Kosei-Nenkin Hospital,undefined
来源：
Nature Medicine | 2006年 / 12卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Ventricular tachycardia is a common and lethal complication after myocardial infarction. Here we show that focal transfer of a gene encoding a dominant-negative version of the KCNH2 potassium channel (KCNH2-G628S) to the infarct scar border eliminated all ventricular arrhythmias in a porcine model. No proarrhythmia or other negative effects were discernable. Our results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias.
引用
收藏
页码：1256 / 1258
页数：2
相关论文
共 50 条
  • [1] Molecular ablation of ventricular tachycardia after myocardial infarction
    Sasano, Tetsuo
    McDonald, Amy D.
    Kikuchi, Kan
    Donahue, J. Kevin
    [J]. NATURE MEDICINE, 2006, 12 (11) : 1256 - 1258
  • [2] Right ventricular radiofrequency ablation of ventricular tachycardia after myocardial infarction
    Menz, V
    Duthinh, V
    Callans, DJ
    Schwartzman, D
    Gottlieb, CD
    Marchlinski, FE
    [J]. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 1997, 20 (06): : 1727 - 1731
  • [3] Radiofrequency catheter ablation of ventricular tachycardia after myocardial infarction
    Stevenson, WG
    Friedman, PL
    Kocovic, D
    Sager, PT
    Saxon, LA
    Pavri, B
    [J]. CIRCULATION, 1998, 98 (04) : 308 - 314
  • [4] Mapping and ablation of polymorphic ventricular tachycardia after myocardial infarction
    Szumowski, L
    Sanders, P
    Walczak, F
    Hocini, M
    Jaïs, P
    Kepski, R
    Szufladowicz, E
    Urbanek, P
    Derejko, P
    Bodalski, R
    Haïssaguerre, M
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 44 (08) : 1700 - 1706
  • [5] Radiofrequency catheter ablation of ventricular tachycardia late after myocardial infarction
    Stevenson, WG
    Friedman, PL
    Ganz, LI
    [J]. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 1997, 8 (11) : 1309 - 1319
  • [6] Ventricular Tachycardia after Myocardial Infarction: Less Events by Catheter Ablation
    Ruchalla, Elke
    [J]. DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2016, 141 (19) : 1352 - U8
  • [7] Radiofrequency ablation of haemodynamically unstable ventricular tachycardia after myocardial infarction
    Furniss, S
    Anil-Kumar, R
    Bourke, JP
    Behulova, R
    Simeonidou, E
    [J]. HEART, 2000, 84 (06) : 648 - 652
  • [8] Radiofrequency catheter ablation for sustained ventricular tachycardia after myocardial infarction
    Stevenson, WG
    Friedman, PL
    Kocovic, DZ
    Sager, PA
    Saxon, LA
    Pavri, BB
    [J]. CIRCULATION, 1996, 94 (08) : 121 - 121
  • [9] Successful Epicardial Catheter Ablation of a Septal Ventricular Tachycardia after Myocardial Infarction
    Yamada, Takumi
    Doppalapudi, Harish
    McElderry, H. Thomas
    Plumb, Vance J.
    Kay, G. Neal
    [J]. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 2012, 35 (05): : e116 - e119
  • [10] Radiofrequency catheter ablation of purkinje system involved ventricular tachycardia after myocardial infarction
    Cui, Yinshi
    Wang, Zulu
    Liang, Yanchun
    Li, Shibei
    Jin, Zhiqing
    Yang, Guitang
    Liang, Ming
    Han, Yaling
    [J]. CARDIOLOGY, 2013, 126 : 101 - 101
12345