Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

被引：0

作者：

Olaf Gross

Hendrik Poeck

Michael Bscheider

Catherine Dostert

Nicole Hannesschläger

Stefan Endres

Gunther Hartmann

Aubry Tardivel

Edina Schweighoffer

Victor Tybulewicz

Attila Mocsai

Jürg Tschopp

Jürgen Ruland

机构：

[1] III. Medizinische Klinik,Department of Biochemistry

[2] Klinikum rechts der Isar,Division of Clinical Pharmacology, Department of Internal Medicine

[3] Technische Universität München,undefined

[4] Ismaninger Str. 22,undefined

[5] 81675 Munich,undefined

[6] Germany ,undefined

[7] University of Lausanne,undefined

[8] Chemin des Boveresses 155,undefined

[9] 1066 Epalinges,undefined

[10] Switzerland,undefined

[11] Ludwig-Maximilian Universität München,undefined

[12] Institute of Clinical Chemistry and Pharmacology,undefined

[13] Universitätsklinikum Bonn,undefined

[14] National Institute for Medical Research,undefined

[15] The Ridgeway,undefined

[16] Mill Hill,undefined

[17] London NW7 1AA,undefined

[18] UK ,undefined

[19] Semmelweis University School of Medicine,undefined

来源：

Nature | 2009年 / 459卷

关键词：

D O I：

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学科分类号：

摘要：

Immunocompromised individuals are at high risk from fungal infection, yet the molecular mechanisms that govern host defence against fungi are not well understood. Gross et al. now show that Candida albicans infection in mice activates the NALP3 inflammasome via a mechanism involving Sky-induced production of reactive oxygen induced by the tyrosine kinase Syk.

引用

页码：433 / 436

页数：3

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