In this paper, we are concerned with the existence and uniqueness of the local solution to the generalized Riemann problem for first order quasi-linear hyperbolic systems of conservation laws in the presence of the shock wave with large amplitude and the centered wave. Apart from some exceptions, we prove the problem admits a unique piecewise smooth solution u=u(t,x), and this solution has a structure similar to the similarity solution u=u(x/t) of the corresponding Riemann problem in the neighborhood of the origin, provided that the coefficients of the system and the initial conditions are sufficiently smooth. The application of our results in rich system is also given.