Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

被引：0
|
作者：
Bryce W. Carey
Lydia W. S. Finley
Justin R. Cross
C. David Allis
Craig B. Thompson
机构：
[1] Laboratory of Chromatin Biology and Epigenetics,
[2] The Rockefeller University,undefined
[3] Cancer Biology and Genetics Program,undefined
[4] Memorial Sloan Kettering Cancer Center,undefined
[5] Donald B. and Catherine C. Marron Cancer Metabolism Center,undefined
[6] Memorial Sloan Kettering Cancer Center,undefined
来源：
Nature | 2015年 / 518卷
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摘要：
If deprived of exogenous glutamine, naive mouse embryonic stem cells are shown to be capable of generating the amino acid from other sources to enable their proliferation; the stem cells use glutamine and glucose catabolism to maintain a high level of intracellular α-ketoglutarate and promote demethylation of chromatin and ensure sufficient expression of pluripotency-associated genes.
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页码：413 / 416
页数：3
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