Cloning and Characterization of KLHL5, a Novel Human Gene Encoding a Kelch-Related Protein with a BTB Domain

被引：0
|
作者：
Shu Wang
Zongxiang Zhou
Kang Ying
Rong Tang
Yan Huang
Chaoqun Wu
Yi Xie
Yumin Mao
机构：
[1] Fudan University,Institute of Genetics, School of Life Science
来源：
Biochemical Genetics | 2001年 / 39卷
关键词：
human ; gene; kelch; BTB domain; BTB/kelch protein; actin binding;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Most kelch family proteins contain two conserved domains, the BTB domain and the kelch repeat domain. Here we describe the cloning and characterization of a novel human KLHL5 gene. The 3488 bp cDNA encodes a kelch family protein homologous to the Drosophila kelch protein. It also contains the two conserved domains. Northern blot analysis reveals a single transcript. It is abundantly expressed in ovary, adrenal gland, and thyroid and less abundantly expressed in trachea, prostate, testis, lymph node, and spinal cord. KLHL5 was mapped to 4p13–4p15.1.
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页码：227 / 238
页数：11
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