Application of an algorithm to analyze patterns of intermittent oral corticosteroid use in asthma

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作者
John Haughney
Trung N. Tran
Heath Heatley
Arnaud Bourdin
Andrew Menzies-Gow
David J. Jackson
Ekaterina Maslova
Jatin Chapaneri
Derek Skinner
Victoria Carter
Jeffrey Shi Kai Chan
David Price
机构
[1] NHS Clinical Research Facilities,Department of Respiratory Diseases
[2] AstraZeneca,UK Severe Asthma Network and National Registry
[3] Observational and Pragmatic Research Institute,UK Severe Asthma Network and National Registry, Guy’s and St Thomas’ NHS Trust and Division of Asthma, Allergy & Lung Biology
[4] Montpellier University Hospitals,Centre of Academic Primary Care, Division of Applied Health Sciences
[5] Arnaud de Villeneuve Hospital,undefined
[6] Royal Brompton & Harefield Hospitals,undefined
[7] King’s College London,undefined
[8] AstraZeneca,undefined
[9] University of Aberdeen,undefined
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摘要
An algorithm to describe patterns of intermittent oral corticosteroid use in the UK (n = 476,167) found that one-third of patients receiving intermittent oral corticosteroids for asthma only had short gaps (<90 days) between oral corticosteroid prescriptions sometime during follow-up. The increasing frequency pattern was more likely in patients with greater asthma severity and with more short-acting β2-agonist use at baseline. Our approach may provide a clinically relevant representation of intermittent oral corticosteroid use in asthma.
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