Heterochromatin links to centromeric protection by recruiting shugoshin

被引：0
|
作者：
Yuya Yamagishi
Takeshi Sakuno
Mari Shimura
Yoshinori Watanabe
机构：
[1] Laboratory of Chromosome Dynamics,Department of Intractable Diseases
[2] Institute of Molecular and Cellular Biosciences,undefined
[3] ,undefined
[4] Graduate Program in Biophysics and Biochemistry,undefined
[5] Graduate School of Science,undefined
[6] and,undefined
[7] ,undefined
[8] Promotion of Independence for Young Investigators,undefined
[9] University of Tokyo,undefined
[10] Yayoi,undefined
[11] Tokyo 113-0032,undefined
[12] Japan ,undefined
[13] International Medical Center of Japan,undefined
来源：
Nature | 2008年 / 455卷
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摘要：
The centromere of a chromosome contains regions of heterochromatin that have diverse roles during chromosome segregation. Here, the authors demonstrate in fission yeast that during mitosis, the main function for centromeric heterochromatin is to recruit cohesin. In contrast, during meiosis, the most important function for heterochromatin is to recruit the cohesin protector shugoshin to centromeres. This function is conserved in human cells.
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页码：251 / 255
页数：4
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