Assembly of microarrays for genome-wide measurement of DNA copy number

被引：0
|
作者：
Antoine M. Snijders
Norma Nowak
Richard Segraves
Stephanie Blackwood
Nils Brown
Jeffrey Conroy
Greg Hamilton
Anna Katherine Hindle
Bing Huey
Karen Kimura
Sindy Law
Ken Myambo
Joel Palmer
Bauke Ylstra
Jingzhu Pearl Yue
Joe W. Gray
Ajay N. Jain
Daniel Pinkel
Donna G. Albertson
机构：
[1] Comprehensive Cancer Center,Department of Laboratory Medicine
[2] University of California San Francisco,undefined
[3] Cancer Research Institute,undefined
[4] University of California San Francisco,undefined
[5] University of California San Francisco,undefined
[6] Roswell Park Cancer Institute,undefined
来源：
Nature Genetics | 2001年 / 29卷
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摘要：
We have assembled arrays of approximately 2,400 BAC clones for measurement of DNA copy number across the human genome. The arrays provide precise measurement (s.d. of log2 ratios=0.05–0.10) in cell lines and clinical material, so that we can reliably detect and quantify high-level amplifications and single-copy alterations in diploid, polyploid and heterogeneous backgrounds.
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页码：263 / 264
页数：1
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