Mixed-lineage kinase control of JNK and p38 MAPK pathways

被引：0
|
作者：
Kathleen A. Gallo
Gary L. Johnson
机构：
[1] Michigan State University,Departments of Physiology and of Biochemistry and Molecular Biology
[2] University of Colorado Health Sciences Center,Department of Pharmacology
来源：
Nature Reviews Molecular Cell Biology | 2002年 / 3卷
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摘要：
Mixed-lineage kinases (MLKs) are serine/threonine-directed protein kinases. The MLK family consists of nine members in the human genome that belong to three subfamilies — MLK, dual-leucine-zipper-bearing kinase (DLK) and zipper sterile-α-motif kinase (ZAK). MLKs are members of mitogen-activated-protein kinase (MAPK) modules that contain c-Jun amino-terminal kinase (JNKs) or p38 MAPKs. MLKs bind the scaffold-like JNK-interacting proteins (JIPs). The Drosophila MLK Slipper regulates epithelial-cell-sheet movements during embryogenesis. MLKs are implicated in the control of neuronal apoptosis, and are potential targets for inhibition in many neurogenerative diseases including Huntington's.
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页码：663 / 672
页数：9
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