Diversity of CRISPR-Cas immune systems and molecular machines

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作者
Rodolphe Barrangou
机构
[1] North Carolina State University,Department of Food, Bioprocessing and Nutrition Sciences
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关键词
Genome Editing; Yersinia Pestis; Vaccination Event; Cas9 Technology; Protospacer Adjacent Motif;
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摘要
Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.
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