Instrumental neutron activation analysis, a technique for measurement of Se, Hg, Fe, Zn, K, Mn, Br, and the Hg:Se ratio in brain tissue samples with results from the Memory and Aging Project (MAP)

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作者
Vivian M. O. Carioni
John D. Brockman
Martha C. Morris
Ruth A. Ngwenyama
Lance A. Schell
Vickie L. Spate
Stacy Crane
机构
[1] University of Missouri Research Reactor Center,Department of Internal Medicine
[2] Rush University,undefined
关键词
Bromine; Potassium; Manganese; Alzheimer’s disease; Instrumental neutron activation analysis;
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摘要
An INAA method for measurement of Se, Hg, Fe, Cr, Zn, Mn, K, and Br in autopsy cerebellum, anterior putamen, white matter, mid-frontal cortex, and inferior temporal lobe. Se, Hg, Fe, Cr, and Zn were measured autopsy samples collected from participants of the Memory and Aging Project. The first study examined the association between seafood consumption, brain Hg and Se, Apolipoprotein E (APOE-ε4) status, and brain neuropathology. Following the initial study, the samples were archived. A subsequent method was developed to measure Mn, K, and Br in the archived brain tissue samples.
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页码:43 / 48
页数:5
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