Considering therapy-induced senescence as a mechanism of tumour dormancy contributing to disease recurrence

被引：0

作者：

Tareq Saleh

David A. Gewirtz

机构：

[1] The Hashemite University,Department of Basic Medical Sciences, Faculty of Medicine

[2] Virginia Commonwealth University,Department of Pharmacology and Toxicology and Medicine, School of Medicine

[3] Virginia Commonwealth University,Massey Cancer Center

来源：

British Journal of Cancer | 2022年 / 126卷

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摘要：

The capability of tumour cells to escape from therapy-induced senescence, as well as cell-non-autonomous functions of senescence, support the premise that senescence could serve as one pathway to tumour dormancy (among others that include quiescence and diapause) that is permissive for disease recurrence. Consequently, the pharmacologic targeting of senescent tumour cells could mitigate the risk for cancer resurgence, thereby enhancing the therapeutic efficacy of cancer chemotherapy.

引用

页码：1363 / 1365

页数：2

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