Single nucleotide polymorphism (SNP);
Japanese population;
High-density SNP map;
Rheumatoid arthritis;
Peptidylarginine deiminase 1 gene;
Peptidylarginine deiminase 3 gene;
D O I:
暂无
中图分类号:
学科分类号:
摘要:
Peptidylarginine deiminases (PADIs) are post-translational modification enzymes that catalyze the conversion of protein-bound arginine residues into citrulline residues in the presence of calcium ions. Among PADIs, PADI4 was identified as a rheumatoid arthritis-susceptibility gene (Suzuki et al. in Nat Genet 34:395, 2003). We identified a total of 87 single nucleotide polymorphisms (SNPs) in PADI1 and PADI3
gene loci. Following a comparison of our data with SNPs in the dbSNP database in the National Center for Biotechnology Information, 45 SNPs are considered to be novel: 33 were identified in the PADI1
gene locus and 12 in the PADI3 gene locus. We also identified two insertion–deletion polymorphisms in introns of the PADI1. The high-resolution map that we constructed in this study will serve as a useful resource for analyzing gene scans of complex diseases mapped to this local segment on chromosomal band 1p36.13.