Synthesis and cytotoxic activity of usnic acid cyanoethyl derivatives

被引:0
|
作者
M. E. Rakhmanova
O. A. Luzina
M. A. Pokrovskii
A. G. Pokrovskii
N. F. Salakhutdinov
机构
[1] Siberian Branch of the Russian Academy of Sciences,N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry
[2] Novosibirsk State University,undefined
来源
Russian Chemical Bulletin | 2016年 / 65卷
关键词
usnic acid; natural dibenzofurans; cyanoethylation; cytotoxicity;
D O I
暂无
中图分类号
学科分类号
摘要
Cyanoethyl derivatives of usnic acid (natural lichen metabolite) were prepared. The reaction proceeded as a C-alkylation process via addition of two acrylonitrile molecules. Cytotoxic effect of the synthesized derivatives on the blood tumor cell lines was studied.
引用
收藏
页码:566 / 569
页数:3
相关论文
共 50 条
  • [1] Synthesis and cytotoxic activity of usnic acid cyanoethyl derivatives
    Rakhmanova, M. E.
    Luzina, O. A.
    Pokrovskii, M. A.
    Pokrovskii, A. G.
    Salakhutdinov, N. F.
    RUSSIAN CHEMICAL BULLETIN, 2016, 65 (02) : 566 - 569
  • [2] Synthesis and cytotoxic activities of usnic acid derivatives
    Bazin, Marc-Antoine
    Le Lamer, Anne-Cecile
    Delcros, Jean-Guy
    Rouaud, Isabelle
    Uriac, Philippe
    Boustie, Joel
    Corbel, Jean-Charles
    Tomasi, Sophie
    BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (14) : 6860 - 6866
  • [3] Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid
    Salimova, E. V.
    Mamaev, A. G.
    Tret'yakova, E. V.
    Kukovinets, O. S.
    Mavzyutov, A. R.
    Shvets, K. Yu.
    Parfenova, L. V.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2018, 54 (09) : 1411 - 1418
  • [4] Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid
    E. V. Salimova
    A. G. Mamaev
    E. V. Tret’yakova
    O. S. Kukovinets
    A. R. Mavzyutov
    K. Yu. Shvets
    L. V. Parfenova
    Russian Journal of Organic Chemistry, 2018, 54 : 1411 - 1418
  • [5] Synthesis and Biological Activity of Usnic Acid Enamine Derivatives
    Luzina, O. A.
    Sokolov, D. N.
    Pokrovskii, M. A.
    Pokrovskii, A. G.
    Bekker, O. B.
    Danilenko, V. N.
    Salakhutdinov, N. F.
    CHEMISTRY OF NATURAL COMPOUNDS, 2015, 51 (04) : 646 - 651
  • [6] Design, synthesis and antimicrobial activity of usnic acid derivatives
    Victor, Kartsev
    Boris, Lichitsky
    Athina, Geronikaki
    Anthi, Petrou
    Marija, Smiljkovic
    Marina, Kostic
    Oliver, Radanovic
    Marina, Sokovic
    MEDCHEMCOMM, 2018, 9 (05) : 870 - 882
  • [7] Synthesis and Biological Activity of Usnic Acid Enamine Derivatives
    O. A. Luzina
    D. N. Sokolov
    M. A. Pokrovskii
    A. G. Pokrovskii
    O. B. Bekker
    V. N. Danilenko
    N. F. Salakhutdinov
    Chemistry of Natural Compounds, 2015, 51 : 646 - 651
  • [8] Usnic Acid Derivatives as Cytotoxic Agents Against Cancer Cells and the Mechanisms of Their Activity
    Guzow-Krzemińska B.
    Guzow K.
    Herman-Antosiewicz A.
    Current Pharmacology Reports, 2019, 5 (6) : 429 - 439
  • [9] Synthesis and cytotoxic evaluation of usnic acid benzylidene derivatives as potential anticancer agents
    Van-Kieu Nguyen
    Sichaem, Jirapast
    Huu-Hung Nguyen
    Xuan Hieu Nguyen
    Thi-Thu-Loi Huynh
    Thi-Phuong Nguyen
    Niamnont, Nakorn
    Dinh-Hung Mac
    Duc-Dung Pham
    Chavasiri, Warinthorn
    Kim-Phi-Phung Nguyen
    Thuc-Huy Duong
    NATURAL PRODUCT RESEARCH, 2021, 35 (07) : 1097 - 1106
  • [10] Design, synthesis and activity evaluation of usnic acid monoesterification derivatives
    Zhang, Qing
    He, Jun-Li
    Zhuo, Xiao-Xia
    Hao, Yi-Meng
    Duan, Hong-Ting
    Jia, Yan
    Wang, Jing-Jing
    Wang, Li-Ning
    NATURAL PRODUCT RESEARCH, 2024,