The Catalytic Mechanism of Nucleoside Diphosphate Kinases

被引：0
|
作者：
Ioan Lascu
Philippe Gonin
机构：
[1] University of Bordeaux-2 and CNRS,Institut de Biochimie et Génétique Cellulaires, UMR 5095
[2] University of Bordeaux-2 and CNRS,Institut de Biochimie et Génétique Cellulaires, UMR 5095
来源：
Journal of Bioenergetics and Biomembranes | 2000年 / 32卷
关键词：
NDP kinase; ping-pong mechanism; phosphohistidine; substrate-assisted catalysis; nucleotide analog;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Nucleoside diphosphate kinases catalyze the reversible transfer of the γ phosphate of nucleosidetriphosphates to nucleoside diphosphates. This minireview presents recent advances inunderstanding the reaction mechanism using steady-state and fast kinetic studies, X-raycrystallography, and site-directed mutagenesis. We also briefly discuss the physiological relevance ofin vitro studies.
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页码：237 / 246
页数：9
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