Mitochondrial Dysfunction as a Signaling Target for Therapeutic Intervention in Major Neurodegenerative Disease

被引:0
|
作者
Shubhada V. Mangrulkar
Nitu L. Wankhede
Mayur B. Kale
Aman B. Upaganlawar
Brijesh G. Taksande
Milind J. Umekar
Md. Khalid Anwer
Hamad Ghaleb Dailah
Syam Mohan
Tapan Behl
机构
[1] Smt. Kishoritai Bhoyar College of Pharmacy,Department of Pharmaceutics, College of Pharmacy
[2] Smt. Shantabai Patil College of Diploma in Pharmacy,Research and Scientific Studies Unit, College of Nursing
[3] SNJB’s Shriman Sureshdada Jain College of Pharmacy,Substance Abuse and Toxicology Research Center
[4] Prince Sattam Bin Abdulaziz University,School of Health Sciences and Technology
[5] Jazan University,Centre for Transdisciplinary Research, Department of Pharmacology
[6] Jazan University,undefined
[7] University of Petroleum and Energy Studies,undefined
[8] Saveetha Dental College,undefined
[9] Saveetha Institute of Medical and Technical Science,undefined
[10] Saveetha University,undefined
来源
Neurotoxicity Research | 2023年 / 41卷
关键词
Mitochondrial dysfunction; Oxidative stress; Mitochondrial quality control; Fusion; Fission; Mitochondrial medicine;
D O I
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中图分类号
学科分类号
摘要
Neurodegenerative diseases (NDD) are incurable and the most prevalent cognitive and motor disorders of elderly. Mitochondria are essential for a wide range of cellular processes playing a pivotal role in a number of cellular functions like metabolism, intracellular signaling, apoptosis, and immunity. A plethora of evidence indicates the central role of mitochondrial functions in pathogenesis of many aging related NDD. Considering how mitochondria function in neurodegenerative diseases, oxidative stress, and mutations in mtDNA both contribute to aging. Many substantial reports suggested the involvement of numerous contributing factors including, mitochondrial dysfunction, oxidative stress, mitophagy, accumulation of somatic mtDNA mutations, compromised mitochondrial dynamics, and transport within axons in neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and Amyotrophic Lateral Sclerosis. Therapies therefore target fundamental mitochondrial processes such as energy metabolism, free-radical generation, mitochondrial biogenesis, mitochondrial redox state, mitochondrial dynamics, mitochondrial protein synthesis, mitochondrial quality control, and metabolism hold great promise to develop pharmacological based therapies in NDD. By emphasizing the most efficient pharmacological strategies to target dysfunction of mitochondria in the treatment of neurodegenerative diseases, this review serves the scientific community engaged in translational medical science by focusing on the establishment of novel, mitochondria-targeted treatment strategies.
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页码:708 / 729
页数:21
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