Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

被引：0

作者：

Philip L De Jager

Xiaoming Jia

Joanne Wang

Paul I W de Bakker

Linda Ottoboni

Neelum T Aggarwal

Laura Piccio

Soumya Raychaudhuri

Dong Tran

Cristin Aubin

Rebeccah Briskin

Susan Romano

Sergio E Baranzini

Jacob L McCauley

Margaret A Pericak-Vance

Jonathan L Haines

Rachel A Gibson

Yvonne Naeglin

Bernard Uitdehaag

Paul M Matthews

Ludwig Kappos

Chris Polman

Wendy L McArdle

David P Strachan

Denis Evans

Anne H Cross

Mark J Daly

Alastair Compston

Stephen J Sawcer

Howard L Weiner

Stephen L Hauser

David A Hafler

Jorge R Oksenberg

机构：

[1] Center for Neurologic Diseases,Division of Molecular Immunology, Department of Neurology

[2] Brigham & Women's Hospital and Harvard Medical School,Division of Genetics, Department of Medicine

[3] Partners Center for Personalized Genetic Medicine,Department of Neurology and Institute for Human Genetics

[4] Program in Medical & Population Genetics,Rush Alzheimer Disease Center & Department of Neurological Sciences

[5] Broad Institute of Harvard University and Massachusetts Institute of Technology,Department of Neurology

[6] Brigham & Women's Hospital,Division of Immunology, Department of Medicine

[7] Harvard Medical School,Hammersmith Hospital and Department of Clinical Neurosciences

[8] School of Medicine,Department of Neurology

[9] University of California,Department of Neurology

[10] San Francisco,Department of Social Medicine

[11] Institute for Human Genetics,Division of Community Health sciences

[12] School of Medicine,Department of Clinical Neurosciences

[13] University of California,undefined

[14] San Francisco,undefined

[15] Rush University,undefined

[16] Washington University,undefined

[17] Allergy and Rheumatology,undefined

[18] Brigham and Women's Hospital,undefined

[19] Miami Institute for Human Genomics,undefined

[20] University of Miami,undefined

[21] Miller School of Medicine,undefined

[22] Center for Human Genetics Research,undefined

[23] Vanderbilt University Medical Center,undefined

[24] GlaxoSmithKline Clinical Imaging Centre,undefined

[25] Imperial College,undefined

[26] University Hospital Basel,undefined

[27] Vrije Universiteit Medical Centre,undefined

[28] University of Bristol,undefined

[29] St. George's,undefined

[30] University of London,undefined

[31] Center for Human Genetic Research,undefined

[32] Massachusetts General Hospital,undefined

[33] University of Cambridge,undefined

[34] Addenbrooke's Hospital,undefined

来源：

Nature Genetics | 2009年 / 41卷

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摘要：

Philip De Jager and colleagues report results of a large genome-wide association and replication study for multiple sclerosis. The work uncovers three new susceptibility loci for MS, including common and rare variants at TNFRSF1A and common variants at IRF8 and CD6.

引用

页码：776 / 782

页数：6

共 17 条

[1] Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
De Jager, Philip L.
Jia, Xiaoming
Wang, Joanne
de Bakker, Paul I. W.
Ottoboni, Linda
Aggarwal, Neelum T.
Piccio, Laura
Raychaudhuri, Soumya
Tran, Dong
Aubin, Cristin
Briskin, Rebeccah
Romano, Susan
Baranzini, Sergio E.
McCauley, Jacob L.
Pericak-Vance, Margaret A.
Haines, Jonathan L.
Gibson, Rachel A.
Naeglin, Yvonne
Uitdehaag, Bernard
Matthews, Paul M.
Kappos, Ludwig
Polman, Chris
McArdle, Wendy L.
Strachan, David P.
Evans, Denis
Cross, Anne H.
Daly, Mark J.
Compston, Alastair
Sawcer, Stephen J.
Weiner, Howard L.
Hauser, Stephen L.
Hafler, David A.
Oksenberg, Jorge R.
NATURE GENETICS, 2009, 41 (07) : 776 - U26
[2] Meta-analysis of Genome Scans and Replication Identify CD6, ICSBP1, and TNFRSF1A as Novel Multiple Sclerosis Susceptibility Loci
De Jager, Philip
de Bakker, Paul
Wang, Joanne
Ottoboni, Linda
Hauser, Stephen
Oksenberg, Jorge
Hafler, David
CLINICAL IMMUNOLOGY, 2009, 131 : S101 - S101
[3] Meta-Analysis of Genome Scans and Replication Identify CD6, ICSBP1, and TNFRSF1A as Novel Multiple Sclerosis Susceptibility Loci
De Jager, Philip
De Bakker, Paul
Wang, Joanne
Compston, Alastair
Sawcer, Stephen
Hauser, Stephen
Hafler, David
Oksenberg, Jorge
NEUROLOGY, 2009, 72 (11) : A492 - A492
[4] Meta-analysis of genome scans and replication identify rare and common multiple sclerosis susceptibility alleles at TNFRSF1A and other loci
De Jager, Philip L.
de Bakker, Paul
Wang, Joanne
Ottoboni, Linda
Hauser, S. L.
Hafler, D. A.
Oksenberg, J.
MULTIPLE SCLEROSIS, 2009, 15 (11): : 1400 - 1401
[5] The Genetic Association of Variants in CD6, TNFRSF1A and IRF8 to Multiple Sclerosis: A Multicenter Case-Control Study
Leppä V.
Surakka I.
Tienari P.J.
Elovaara I.
Compston A.
Sawcer S.
Robertson N.
de Jager P.L.
Aubin C.
Hafler D.A.
Oturai A.B.
Søndergaard H.B.
Sellebjerg F.
Sørensen P.S.
Hemmer B.
Cepok S.
Winkelmann J.
Wichmann H.-E.
Comabella M.
Bustamante M.F.
Montalban X.
Olsson T.
Kockum I.
Hillert J.
Alfredsson L.
Goris A.
Dubois B.
Mero I.-L.
Smestad C.
Celius E.G.
Harbo H.F.
D'Alfonso S.
Bergamaschi L.
Leone M.
Ristori G.
Kappos L.
Hauser S.L.
Cournu-Rebeix I.
Fontaine B.
Boonen S.
Polman C.
Palotie A.
Peltonen L.
Saarela J.
PLOS ONE, 2011, 6 (04):
[6] Associations of CD6, TNFRSF1A and IRF8 polymorphisms with risk of inflammatory demyelinating diseases
Park, T. -J.
Kim, H. J.
Kim, J. -H.
Bae, J. S.
Cheong, H. S.
Park, B. -L.
Shin, H. D.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2013, 39 (05) : 519 - 530
[7] Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain
Swaminathan, Bhairavi
Matesanz, Fuencisla
Cavanillas, Maria L.
Alloza, Iraide
Otaegui, David
Olascoaga, Javier
Cenit, Maria C.
de las Heras, Virgina
Garcia Barcina, Maria
Arroyo, Rafael
Alcina, Antonio
Fernandez, Oscar
Antigueedad, Alfredo
Urcelay, Elena
Vandenbroeck, Koen
JOURNAL OF NEUROIMMUNOLOGY, 2010, 223 (1-2) : 100 - 103
[8] Validation of the CD6, TNFRSF1A and IRF5 genes in multiple sclerosis in Spain
Bhairavi, Swaminathan
Fuencisla, Matesanz
Maria, Cavanillas
Iraide, Alloza
David, Otaegui
Javier, Olascoaga
Carmen, Cenit M.
de las Heras, Virgina
Maria Garcia, Barcina
Rafael, Arroyo
Antonio, Alcina
Oscar, Fernandez
Alfredo, Antiguedad
Elena, Urcelay
Koen, Vandenbroeck
JOURNAL OF NEUROIMMUNOLOGY, 2010, 228 (1-2) : 51 - 52
[9] Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci
Tsoi, Lam C.
Spain, Sarah L.
Ellinghaus, Eva
Stuart, Philip E.
Capon, Francesca
Knight, Jo
Tejasvi, Trilokraj
Kang, Hyun M.
Allen, Michael H.
Lambert, Sylviane
Stoll, Stefan W.
Weidinger, Stephan
Gudjonsson, Johann E.
Koks, Sulev
Kingo, Kulli
Esko, Tonu
Das, Sayantan
Metspalu, Andres
Weichenthal, Michael
Enerback, Charlotta
Krueger, Gerald G.
Voorhees, John J.
Chandran, Vinod
Rosen, Cheryl F.
Rahman, Proton
Gladman, Dafna D.
Reis, Andre
Nair, Rajan P.
Franke, Andre
Barker, Jonathan N. W. N.
Abecasis, Goncalo R.
Trembath, Richard C.
Elder, James T.
NATURE COMMUNICATIONS, 2015, 6
[10] Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci
Lam C. Tsoi
Sarah L. Spain
Eva Ellinghaus
Philip E. Stuart
Francesca Capon
Jo Knight
Trilokraj Tejasvi
Hyun M. Kang
Michael H. Allen
Sylviane Lambert
Stefan W. Stoll
Stephan Weidinger
Johann E. Gudjonsson
Sulev Koks
Külli Kingo
Tonu Esko
Sayantan Das
Andres Metspalu
Michael Weichenthal
Charlotta Enerback
Gerald G. Krueger
John J. Voorhees
Vinod Chandran
Cheryl F. Rosen
Proton Rahman
Dafna D. Gladman
Andre Reis
Rajan P. Nair
Andre Franke
Jonathan N.W.N. Barker
Goncalo R. Abecasis
Richard C. Trembath
James T. Elder
Nature Communications, 6

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