Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

被引：0

作者：

Brian D Gulbransen

Mohammad Bashashati

Simon A Hirota

Xianyong Gui

Jane A Roberts

Justin A MacDonald

Daniel A Muruve

Derek M McKay

Paul L Beck

Gary M Mawe

Roger J Thompson

Keith A Sharkey

机构：

[1] Hotchkiss Brain Institute,Department of Physiology and Pharmacology

[2] University of Calgary,Department of Medicine

[3] University of Calgary,Department of Biochemistry and Molecular Biology

[4] Snyder Institute of Infection,Department of Pathology and Laboratory Medicine

[5] Immunity and Inflammation,Department of Anatomy & Neurobiology

[6] University of Calgary,Department of Cell Biology and Anatomy

[7] University of Calgary,undefined

[8] Libin Cardiovascular Institute,undefined

[9] University of Calgary,undefined

[10] University of Calgary,undefined

[11] University of Calgary,undefined

[12] University of Vermont College of Medicine,undefined

[13] University of Calgary,undefined

来源：

Nature Medicine | 2012年 / 18卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Enteric neuron death is linked to the pathogenesis of inflammatory bowel disease. Now, Brian Gulbransen and his colleagues demonstrate that P2X7 receptor–pannexin-1 signaling is responsible for enteric neuron death in mouse models of colitis.

引用

页码：600 / 604

页数：4

共 50 条

[1] Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis
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[2] Functional Coupling between the P2X7 Receptor and Pannexin-1 Channel in Rat Trigeminal Ganglion Neurons
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[3] Activating Neuronal P2X7-Pannexin-1 Mediates Inflammation-Induced Enteric Neuron Death
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[9] Pannexin 1 as the pore forming unit of the P2X7 receptor death complex
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[10] Differential effects of experimental ulcerative colitis on P2X7 receptor expression in enteric neurons
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