A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4+ CD25+ FOXP3+ Tregs that inhibit experimental autoimmune encephalomyelitis (EAE)

被引:0
|
作者
Cody D. Moorman
Alexander G. Bastian
Kayla B. DeOca
Mark D. Mannie
机构
[1] East Carolina University,Department of Microbiology and Immunology, Brody School of Medicine
关键词
FOXP3; Tregs; Immune tolerance; Tolerogenic vaccine; EAE/MS; Neuroimmunology; GM-CSF; Neuroantigen;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 5 条
  • [1] A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4+CD25+FOXP3+Tregs that inhibit experimental autoimmune encephalomyelitis (EAE)
    Moorman, Cody D.
    Bastian, Alexander G.
    DeOca, Kayla B.
    Mannie, Mark D.
    JOURNAL OF NEUROINFLAMMATION, 2020, 17 (01)
  • [2] MicroRNA 182 inhibits CD4+ CD25+ Foxp3+ Treg differentiation in experimental autoimmune encephalomyelitis
    Wan, Cong
    Ping, Chang-Yun
    Shang, Xiao-Yu
    Tian, Jiang-Tian
    Zhao, Si-Han
    Li, Lei
    Fang, Shao-Hong
    Sun, Wei
    Zhao, Yan-Feng
    Li, Zhao-Ying
    Xu, Yan-Wen
    Mu, Li-Li
    Wang, Jing-Hua
    Kong, Qing-Fei
    Wang, Guang-You
    Li, Hu-Lun
    Sun, Bo
    CLINICAL IMMUNOLOGY, 2016, 173 : 109 - 116
  • [3] Depletion of CD4+ CD25+ regulatory T cells confers susceptibility to experimental autoimmune encephalomyelitis (EAE) in GM-CSF-deficient Csf2-/- mice
    Ghosh, Debjani
    Curtis, Alan D., II
    Wilkinson, Daniel S.
    Mannie, Mark D.
    JOURNAL OF LEUKOCYTE BIOLOGY, 2016, 100 (04) : 747 - 760
  • [4] Microparticle-delivered stimulator of interferon genes (STING) agonist suppresses experimental autoimmune encephalomyelitis (EAE) via expansion of FoxP3+ CD4+ Tregs
    Elzoheiry, Manal Ali
    Wang, Yan
    Kasimoglu, Ezgi
    Seyedsadr, Maryamsadat
    Batty, Cole
    Bachelder, Eric
    Kristy, Ainslie
    Markovic-Plese, Silva
    JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
  • [5] A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4+ CD25high FOXP3+ Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-Efficiency T Cell Antigen Receptor Recognition
    Moorman, Cody D.
    Curtis, Alan D., II
    Bastian, Alexander G.
    Elliott, Sarah E.
    Mannie, Mark D.
    FRONTIERS IN IMMUNOLOGY, 2019, 9