Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis

被引：0

作者：

Doris Berchtold

Manuele Piccolis

Nicolas Chiaruttini

Isabelle Riezman

Howard Riezman

Aurélien Roux

Tobias C. Walther

Robbie Loewith

机构：

[1] Max Planck Institute of Biochemistry,Department of Molecular Biology

[2] Organelle Architecture and Dynamics,Department of Biochemistry

[3] University of Geneva,Department of Cell Biology

[4] University of Geneva,undefined

[5] Swiss National Centre for Competence in Research Programme Chemical Biology,undefined

[6] Yale University School of Medicine,undefined

[7] New Haven,undefined

[8] Swiss National Centre for Competence in Research Programme Frontiers in Genetics,undefined

来源：

Nature Cell Biology | 2012年 / 14卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The lipid content of the plasma membrane is dynamically regulated to maintain cellular homeostasis, but the molecular links between membrane stress and sphingolipid synthesis have remained elusive. Walther, Loewith and colleagues report that membrane stretching causes redistribution of Slm proteins, which then promote sphingolipid synthesis through activation of the TORC2–Ypk signalling pathway.

引用

页码：542 / 547

页数：5

共 45 条

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