Effects of Temperature and Mobile Phase Condition on Chiral Recognition of Poly(l-phenylalanine) Chiral Stationary Phase

被引：0
|
作者：
Kaname Ohyama
Kana Oyamada
Naoya Kishikawa
Mitsuhiro Wada
Yoshihito Ohba
Kenichiro Nakashima
Naotaka Kuroda
机构：
[1] Nagasaki University,Department of Environmental and Pharmaceutical Sciences, Course of Pharmaceutical Sciences, Graduate School of Biomedical Sciences
[2] Nagasaki University,Department of Clinical Pharmacy, Graduate School of Biomedical Sciences
[3] Nagasaki International University,Faculty of Pharmaceutical Sciences
来源：
Chromatographia | 2011年 / 74卷
关键词：
Chiral stationary phase; Column temperature; Helical conformation; -Phenylalanine; Mobile phase condition;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Characteristics of the chiral stationary phase with poly(l-phenylalanine) peptide selector, which was in α-helical state, was reported. Since environmental factors affect peptide conformation, the changes in enantioselectivity were examined depending on column temperature and mobile phase conditions (ionic strength, pH, mobile phase composition). Column temperature and pH drastically affected the enantioselectivity. Based on these changes, the relation between chiral recognition and secondary structure of the peptide selector was discussed. The column stability during sequential analysis under different separation conditions was also evaluated.
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页码：467 / 470
页数：3
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