Functional immobilization of signaling proteins enables control of stem cell fate

被引：0
|
作者：
Kristin Alberti
Ryan E Davey
Kento Onishi
Sophia George
Katrin Salchert
F Philipp Seib
Martin Bornhäuser
Tilo Pompe
Andras Nagy
Carsten Werner
Peter W Zandstra
机构：
[1] Leibniz Institute of Polymer Research Dresden,
[2] Max Bergmann Center of Biomaterials,undefined
[3] Institute of Biomaterials and Biomedical Engineering,undefined
[4] 164 College Street,undefined
[5] University of Toronto,undefined
[6] Samuel Lunenfeld Research Institute,undefined
[7] Mount Sinai Hospital,undefined
[8] University Hospital Carl Gustav Carus,undefined
[9] Dresden University of Technology,undefined
[10] Center for Regenerative Therapies Dresden,undefined
[11] Chemical Engineering and Applied Chemistry,undefined
[12] University of Toronto,undefined
来源：
Nature Methods | 2008年 / 5卷
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摘要：
Cells in vivo are exposed not only to soluble factors but also to immobilized ligands. Controlled immobilization of functional growth factors yields dose-dependent responses in mouse embryonic stem cells in vitro and allows the effects of immobilized versus soluble ligands to be studied.
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页码：645 / 650
页数：5
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