Abolition of endothelium-dependent relaxation in the rat aorta by tetraoctylammonium ions

被引：0
|
作者：
Yu Huang
X.Q. Yao
F.L. Chan
C.W. Lau
N.W.K. Chan
Z.Y. Chen
机构：
[1] Department of Physiology,
[2] The Chinese University of Hong Kong,undefined
[3] Shatin,undefined
[4] Hong Kong,undefined
[5] China,undefined
[6] Department of Anatomy,undefined
[7] The Chinese University of Hong Kong,undefined
[8] Shatin,undefined
[9] Hong Kong,undefined
[10] China,undefined
[11] Department of Biochemistry,undefined
[12] The Chinese University of Hong Kong,undefined
[13] Shatin,undefined
[14] Hong Kong,undefined
[15] China,undefined
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 2000年 / 362卷
关键词：
Tetraoctylammonium ions Endothelium Nitric oxide Cyclic GMP Relaxation Aorta Rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Quaternary ammonium ions are common pharmacological probes used to study the kinetic properties of K+ channels in smooth muscle cells. On the other hand, some ammonium compounds cause vasorelaxation through unknown mechanisms. The main aim of this study was to examine a unique role of endothelium in the vascular response to tetraoctylammonium ions (TOA+) in the isolated rat aorta. Changes in contractile force were measured by force transducers and total tissue content of cGMP was measured by radioimmunoassay. Endothelial cytosolic Ca2+ ([Ca2+]i) was assessed by laser scanning confocal microscopy.
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页码：152 / 159
页数：7
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