Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation

被引:0
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作者
L. F. Porrata
S. N. Markovic
机构
[1] Mayo Clinic,Division of Hematology, Department of Internal Medicine
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Absolute lymphocyte count; Natural killer cells; Autologous stem cell transplantation; Kinetics; Clinical outcome;
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摘要
The anti-tumor activity of the immune system in the setting of hematopoietic stem cell transplantation has largely been described in the context of the “graft-versus-tumor” effect of allogeneic stem cell transplantation. This article reviews clinical evidence suggesting the existence of an autologous graft-versus-tumor effect in the setting of host immune system recovery following autologous stem cell transplantation resulting in prolongation of survival of cancer patients.
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页码:78 / 85
页数:7
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