Experimental and Clinical Pharmacokinetics of Amitryptiline: Comparative Analysis

被引：0
|
作者：
V. G. Kukes
S. N. Kondratenko
M. I. Savelyeva
A. K. Starodubtsev
E. T. Gneushev
机构：
[1] I.M. Sechenov Moscow Medical Academy,Department of Clinical Pharmacology and Propedeutics of Internal Disease
[2] Federal Agency of High-Technology Medical Service,Laboratory of Drug Toxicology, Russian Cardiologic Research and Production Complex
来源：
Bulletin of Experimental Biology and Medicine | 2009年 / 147卷
关键词：
amitriptyline; pharmacokinetics; serum concentration; apparent bioavailability;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Pharmacokinetics of two amitriptyline tablets, Amitryptiline Nycomed and Amitryptiline, was investigated clinically and experimentally after a single oral dose of 50 mg. A statistically significant correlation between amitryptiline serum concentrations in dogs and healthy humans (r=0.683, p<0.006) was established. In humans, standartized values of peak concentration and area under the concentration curve were significantly higher, specific volume of distribution and total clearance were lower, and half-life and mean retention time were significantly higher than in dogs. Characteristics of apparent bioavailability in dogs and healthy people did not statistically differ.
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页码：434 / 437
页数：3
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