Forced convection heat transfer and pressure drop characteristics of air flow inside a horizontal semi-circular duct are investigated experimentally. The experiments are carried out on a semi-circular duct of 23 mm inner radius, 2 mm thickness, and 2,000 mm length within a range of Reynolds number (8,242 ≤ Re ≤ 57,794)., under uniform wall heat flux conditions. The friction factor is determined by measuring the axial static pressure at different selected axial stations along the semi-circular duct. The variations of surface and mean air temperatures, local heat transfer coefficient, local Nusselt number, and the friction factor with the axial dimensionless distance are presented. It is observed that, for a given value of Reynolds number, each of the local heat transfer coefficient and the friction factor has a relatively high value near the entrance of the semi-circular duct then it decreases with increasing the dimensionless axial distance until it approaches a nearly constant value at the fully developed region. Also, it is found that, with increasing the Reynolds number the average heat transfer coefficient is increased and the friction factor is decreased. Moreover, empirical correlations for the heat transfer coefficient and friction factor as a function of the Reynolds number are obtained.