Loss-of-function of zebrafish cdt1 causes retarded body growth and underdeveloped gonads resembling human Meier-Gorlin syndrome

被引：0

作者：

He, Yinan ^{[1
]}

Wang, Yong ^{[2
]}

Zhu, Yanqing ^{[1
]}

Lo, Li Jan ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Anim Sci, MOE Key Lab Mol Anim Nutr, Hangzhou 310058, Peoples R China

[2] Zhejiang Univ, Pathol Dept, Taizhou Hosp, Taizhou 317000, Peoples R China

来源：

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 2023年 / 24卷 / 11期

基金：

中国国家自然科学基金;

关键词：

N??; cdt1-201; cdt1-202; ORIGIN RECOGNITION COMPLEX; DNA-REPLICATION; INHIBITION; PROTEIN;

D O I：

10.1631/jzus.B2300195

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

????????DNA????1(Cdt1)??????????????,??????????????????????Cdt1?????,????????????????DNA??????Cdt1???????DNA????,??????????????cdt1???Meier-Gorlin???(MGS)???CDT1??????,?????????????????????????????(?????),Cdt1????N???????????????????????????cdt1??????????????????(???cdt1(zju1)),???????????????????????,?????????????????????????,???????????,?????????cdt1-201?,?????????cdt1??--cdt1-202,?????????2??,????????????????cdt1-202?cdt1-201??????????????????,cdt1-202????????cdt1-201????????????,????????,?????????????MGS??????

引用

页码：1037 / 1046

页数：10

共 2 条

[1] Successful pregnancies in an adult with Meier-Gorlin syndrome harboring biallelic CDT1 variants
Knapp, Karen M.
Murray, Jennie
Temple, I. Karen
Bicknell, Louise S.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2021, 185 (03) : 871 - 876
[2] A novel homozygous intronic variant in CDT1 that alters splicing causes Meier-Gorlin syndrome, and a review of published mutations and growth hormone treatments
Li, Qing
Wu, Yichi
Meng, Fucheng
Li, Zhuxi
Zhan, Di
Luo, Xiaoping
ORPHANET JOURNAL OF RARE DISEASES, 2024, 19 (01)

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